and Kostis, W.J. Crestor Called Less Safe than Other Statins. Statins and Liver Injury. In other words, low cholesterol levels may increase the risk of blood-vessel rupture. Retrieved, Anderson, M. (2014, May 14). (2004, June 26). But the general hypothesis is that cholesterol may somehow be important to cell-wall integrity. For more information, visit our sponsors page. Keep people safe from potentially harmful drugs, medical devices and procedures by informing them of medical conditions, severe side effects and ways to take action. Retrieved, O’Riordan, M. (2012, August 13). How Long Does Coronavirus Live On Surfaces? The condition is considered rare. Drugwatch's sponsors support the organization's mission to keep people safe from dangerous drugs and medical devices. (2015, August). Recurrence has been reported among people who restart Crestor. New Findings on Statin-Memory Loss Link. Myopathy is a group of disorders in which muscle fibers do not function properly. Rosuvastatin Calcium (Marketed as Crestor) Information. Retrieved, FDA. (n.d.) Rhabdomyolysis. Do Not Sell My Info. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Several studies have found a higher risk of hemorrhagic stroke in populations with low cholesterol levels. Other possible serious side effects of statins include hemorrhagic stroke, Type 2 diabetes and liver damage. This condition can be detected and differentiated from myalgia by tests that reveal toxic levels of muscle enzymes. JUPITER Analysis Helps Assuage Fears About Diabetes Risk with Statins. Retrieved, Goodarzi, M.O. The recovery time averages about three weeks. Reviewer specialties include internal medicine, gastroenterology, oncology, orthopedic surgery and psychiatry. Studies have shown this side effect occurs in about 3 percent of patients taking statins. Retrieved, Amarenco, P. et al. It tells health care professionals to advise patients to “report unexplained muscle pain, tenderness, or weakness.” The warning mentions myopathy and rhabdomyolysis specifically. The agency based its decision on studies and adverse event reports. The drug may also be linked to decreased cognition, such as memory loss and amnesia. Magazine, R. and Bairy, K.L. Retrieved, AstraZeneca. (2016, November 15). Stomach Cramps (2008, November 20). But the FDA required AstraZeneca to add the condition to Crestor’s label. Statin Use and Risk of Diabetes Mellitus. In 2005, the FDA required Crestor’s manufacturer, AstraZeneca, to add a warning to the drug’s label. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Statin-Induced Rhabdomyolysis: A Comprehensive Review of Case Reports. Relationship of Sex to Diabetes Risk in Statin Trials. et al. Generalized Weakness 2. Retrieved, Mendes, P. et al. Rhabdomyolysis is a type of skeletal muscle damage that can lead to kidney damage and sometimes death. Selected from data included with permission and copyrighted by First Databank, Inc. Retrieved, Harvard Medical School. Researchers found the diabetes risk increased to 48 percent among women taking statins. (2016, January). Retrieved, Liao, J.K. (2006, December 15). Join our newsletter to stay up to date on dangerous drugs and devices, keep up on lawsuit and settlement news, learn about FDA recalls, and more. If you found our resources and information helpful, please take a minute to review us on Facebook and Google. Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease. Safety and Efficacy of Statins in Asians. FDA Drug Safety Communication: Important Safety Label Changes to Cholesterol-Lowering Drugs. Crestor is a statin like Lipitor. However, as required by the new California Consumer Privacy Act (CCPA), you may record your preference to view or remove your personal information by completing the form below. (2015, July 10). Crestor Label. Head Pain 3. © 2020 Drugwatch.com Privacy Policy/ Hemorrhagic Stroke. We appreciate your feedback. (2018, January 8). Retrieved, Thapar, M. et al. Retrieved from. Safety and Statins: Pharmacologic and Clinical Perspectives. Review our editorial policy to learn more about our process for producing accurate, current and balanced content. Scientists have not determined the exact cause. (2005, March 10). Crestor’s side effects range from common, relatively mild reactions such as headaches to a rare, severe condition called rhabdomyolysis, which has been linked to kidney damage and death. Rhabdomyolysis causes skeletal muscle tissue to break down rapidly and travel into the bloodstream. Crestor May Pose Risk of Muscle Damage. The U.S. Food and Drug Administration approved Crestor (rosuvastatin) for treating cholesterol in 2003. PRN is a nationally recognized leader in providing independent medical reviews. Drugwatch.com is sponsored by law firms. This site complies with the HONcode standard for trustworthy health information: Verify here. (2014, August). Retrieved, Thompson, P.D. Statin Side effects: How common are they? (2012, February 1). Reports included cases of memory loss, forgetfulness, amnesia, memory impairment and confusion. But in the drug’s first year, the number of rhabdomyolysis cases among Crestor users was higher than for other statins. Drugwatch is located at: Retrieved, Heo, J.H. Retrieved, Alsheikh-Ali, A.A. et al. Prior results do not predict a similar outcome. Retrieved, Wolfe, S.M. et al. Statins may possibly increase the risk of a hemorrhagic stroke. (2013, July). (2012, August). (n.d.). (2014, April 25). This website and its content may be deemed attorney advertising. Please seek the advice of a medical professional before making health care decisions. One type of debris created in this muscle breakdown is a protein called myoglobin. Effect and Safety of Rosuvastatin in Acute Ischemic Stroke. ALERT: Your health is top priority. The information on this website is proprietary and protected. High-Dose Atorvastatin after Stroke or Transient Ischemic Attack. Crestor’s label carries a warning about skeletal muscle effects. One of our content team members will be in touch with you soon. They found a 27 percent increase in the risk of patients developing diabetes. Patients should not stop taking a prescription drug without consulting a doctor. Cases of cognitive impairment have been reported in patients using Crestor and other statins. She joined Drugwatch in 2017. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Side effects not requiring immediate medical attention Body aches or pain congestion dry or sore throat runny nose tender, swollen glands in the neck voice changes For more information, visit our sponsors page. Retrieved, National Stroke Association. In addition, there have been reports of memory loss possibly linked to Crestor use. Retrieved, Bottorff, M.B. Are taking certain other medicines while … Patients who catch liver injury quickly can recover within one to two months after stopping the drug. 1 South Orange Ave, Suite 201, Orlando, FL 32801. Calling this number connects you with a Drugwatch representative. The Safety of Rosuvastatin as Used in Common Clinical Practice; A Postmarketing Analysis. If experienced, these tend to have a Severe expression, If experienced, these tend to have a Less Severe expression. Retrieved, Ridker, P.M. et al. Nausea 4. The conditions are reversible by discontinuing the drug temporarily. Warning signs of rhabdomyolysis include muscle aches and dark-colored urine. Retrieved, Public Citizen. Crestor may also increase the chances of liver damage and diabetes. Your chances of getting muscle problems are higher if you: In 2005, a study in the American Heart Association journal Circulation found patients taking Crestor were eight times more likely to develop rhabdomyolysis, renal failure or proteinuria — high levels of protein in the urine — than patients taking certain other statins. Side Effects of Crestor. (2006, August 10). AstraZeneca recommends doctors order blood tests to check patients’ livers before prescribing the drug. Sign Up to Receive Our Free Coroanvirus Newsletter, A Condition With Muscle Tissue Breakdown Called Rhabdomyolysis, A Disease With Shrinking And Weaker Muscles Called Myopathy, A Type Of Allergic Reaction Called Angioedema, A Yellowing Of The Eyes Or Skin From Buildup Of Bilirubin Called Jaundice, Inflammation Of The Liver Called Hepatitis, A Painful Condition That Affects The Nerves In The Legs And Arms Called Peripheral Neuropathy.
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