We conducted an observational study using IMS Health data for the period February 2006–January 2010. Eikelboom J
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The average dose of atorvastatin sold was 16.2 milligrams per day in February 2006. Akdim F
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24 No polypill was available in India during the study period, as noted above. ,
50, We observed substantial increases in statin use between 2006 and 2009. Thus, atorvastatin—which was sold in the United States only as a brand-name drug during our study period—had a lower price in India than simvastatin does. 14,15 Indian stockists are selected for inclusion in the database based on their location. van der Velde G
The study found that 1 in 10 Canadian adults was taking statins, but this fell far short of the 1 in 4 who would be recommended for treatment under the guidelines. ,
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59–61 The National Pharmaceutical Pricing Authority of India has recommended imposing a ceiling price for atorvastatin, limiting retailers to a margin of 16 percent. , Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. Haynes RB, Interventions to enhance medication adherence in chronic medical conditions: a systematic review, Wald NJ
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Choudhry NK, A systematic review of adherence to cardiovascular medications in resource-limited settings, Choudhry NK
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x�%̱�0����5Qz�1��QF�{���О���큸|�w2�E 鈱��`8ơGH��M�iT߆]ֈ~��c|�}���W����M��b2�y�4��2�Z2�.�]hm� From the IMS Health data, we calculated the number of month-long supplies of medications sold (referred to in this article as prescriptions). Per capita prescribing rates for statins in India are twenty times lower than those in the United States and Canada. Afzal R
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<>>>/BBox[0 0 585 783]/Length 116>>stream 4,5 In contrast, cholesterol levels are increasing among people in low- and middle-income countries, 4 where cardiovascular disease already accounts for more deaths than in higher-income countries. 45,46, In 2004 the fifty largest pharmaceutical manufacturers in India spent 290–1,025 percent more on drug promotion than they did on research and development. Using this measure makes it possible to make comparisons across medications with different relative potencies. Pais P
<>stream Exhibit 3 Statin Prescriptions Per 1,000 Population And 1,000 Patients With Coronary Heart Disease (CHD), February 2006–January 2010. 31 Similarly, studies have raised questions about the benefits of combining statins and ezetimibe 32 and of adding niacin to an optimal statin regimen. from application/x-indesign to application/pdf SOURCE Authors’ analysis of data from IMS Health’s Stockist Sales Audit database. Exhibit 4 Statin Prescriptions Per 1,000 Population, By Statin Type, February 2006–January 2010, Exhibit 5 Annual Statin Sales In India, 2006–09. Antiplatelet agents and nonstatin cholesterol-lowering agents, particularly ezetimibe (combined with atorvastatin, rosuvastatin, or simvastatin) and fibrates (combined with atorvastatin or rosuvastatin), were the most common drug classes combined with statins. 2, 24 January 2019 | BMJ Open, Vol. Pogue J
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Their current statin use was then compared with their risk. ,
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We used aggregate prescription sales data and did not have access to detailed patient-level clinical information. Gregory Brill is a statistical programmer in the Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital. ,
Pfeffer MA
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Click to see a list of surveys that STATIN will be undertaking in 2019. We recently observed that statin utilisation is higher in Stockholm, Sweden, which is a relatively high-risk area, compared to Sicily, Italy, with a lower population risk level.32 However, the analysis of the time trend of changes in Bana A
The rate of statin prescriptions sold daily in January 2010 was 3.4 per 1,000 population and 84.1 per 1,000 patients with CHD ( Exhibit 1 ). Pais P
Laxminarayan R, Selvaraj S
Wald NJ, Randomized polypill crossover trial in people aged 50 and over. The result is higher sales of brand-name medications than would be the case for patients with higher levels of health literacy. 18, No. Combination products cost less than statins alone (5.0 versus 6.2 rupees per pill; p<0.001 ). ,
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49 The council has also revised its code of conduct to deregister physicians who accept gifts worth more than 100,000 rupees (US$1,577.97), but addressing potential conflicts of interest remains challenging. 25,26. However, with prescription rates of approximately 8,000 per 100,000 patients with CHD in January 2010, only a minority of patients who would receive statin therapy in other countries appear to be receiving the therapy in India. Moye LA
SOURCE Authors’ analysis of IMS Health’s Stockist Sales Audit database. 62 Whether this will increase overall rates of use remains unknown. Buck G
Anand S, Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization, Gupta R
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