The cascade of pro-inflammatory cytokines is a response to vascular trauma, not the cause of it. Finally, and most recently we have reassuring evidence from Australian researchers who meticulously studied over a thousand participants aged 70-90 years in the Sydney Memory and Ageing Study. All that logically follows a premise of inflammation causality needs to be reevaluated. You must look farther upstream for actual causes. Inflammation is the body’s first response in the healing process. I informed him that there is no evidence that rosuvastatin causes diarrhea more often than a placebo and had no reason based on its chemistry to suspect it would. WEDNESDAY, Feb. 27, 2019 (HealthDay News) -- While effective at cutting heart risks, blood pressure and cholesterol drugs may not help preserve seniors' brain health, new research finds. According to the Alzheimer’s Society, medical evidence suggests there is a link between high cholesterol during mid-life and development of dementia. The study, which analysed 44,920 Swedish dementia patients from the Swedish Dementia Registry between 2008-2015, found users of statins had a … He also made a cautionary statement on the findings. In fact, it is the leading cause of death in the United States. This study was supported by the Australian Government’s National Health and Medical Research Council (Dementia Research Grant 510124). Since one in five Americans between the ages of 40 and 75 take these drugs regularly, it is likely that you are acquainted with at least one person who is doing so. A certain percentage of such patients are going to notice memory loss independent of any medications. Despite this, a common concern of my patients when we discuss potentially utilizing statin drugs to reduce their long term risk of heart attack and stroke is that the drug will rob them of their memory. The role that cholesterol in the brain plays in the development of dementia is also being investigated, and there are lots of avenues for this research to take. At the same time, there has been an astronomical increase in the number of people experiencing memory loss, dementia and Alzheimerâs disease, which is now the sixth leading cause of death in the United States. According to the Alzheimer’s Society, medical evidence suggests there is a link between high cholesterol during mid-life and development of dementia. Thank you for this amazing article. One of the highest-ranking search results links to an article titled “The Grave Dangers of Statin Drugs—and the Surprising Benefits of Cholesterol”. I am so pleased to have stumbled on your site. People are generally only told about the link between cholesterol and heart disease, but cholesterol also has incredibly important functions in the body. This is in the setting of primary prevention-those that haven’t yet had a heart attack or sudden death. More recently, multiple reviews and meta-analyses have examined the data and concluded that there is no significant effect of statins on cognitive function. I can’t bring myself to take a statin nor can I recommend others take it in similar circumstances. And I’m fine with that. It has been suggested that high levels of cholesterol in the serum (part of the blood) may increase the risk of dementia and that treatment with cholesterol-lowering medicines such as statins may reduce the risk of dementia. Cutler’s website appears to engage in fear-mongering with respect to statins for the purpose of selling his books and promoting his “integrative” practice. ( I’m retired, he’s not) Together we co-authored close to a dozen articles in peer reviewed journals. Statin drugs, prescribed by doctors to reduce high cholesterol levels and supposedly prevent heart attacks and strokes, are the second most prescribed drugs in the world, after the painkiller hydrocodone. Statins and memory loss. I am skeptical regarding the benefit of statins in low risk individual despite my physician quoting stats that I should take it to reduce my risk further. As noted by the organization Be Brain Fit (BBF), there has been a massive increase in the number of Americans taking statin drugs like Crestor and Lipitor in recent years. Does that mean that the benefits of taking statin drugs outweigh the risks? BBF suggests that these two statistics may be no coincidence. I’m pleased as punch that I my skeptical articles are well received by those filled with skepticism! In 2017 I wrote a post entitled “Do Statins Cause Memory Loss?The Science, The Media, The Statin-Denialist Cult, and The Nocebo Effect” which concluded that there was no scientific evidence for cognitive side effects of the widely-utilized statin cholesterol lowering drugs.. Can statins effectively treat or prevent heart disease? If the side effect is significant I will generally tell the patient to stop the statin and report to me how they feel after two to four weeks. Is it true that the average patient would need to take statins for 5 years in order to see life expectancy increased by 5 days? There is no scientific evidence to suggest statins cause dementia. It annoys the hell out of people who know me. Fortunately he accepted my expert opinion and will continue taking the drug. Neurotransmitters are also responsible for regulating mood, as well as facilitating focus and the ability to remember things, learn new things and cope with stress. Mike, The reasons for patient noncompliance, Nissen goes on to say, can be related to the promotion of totally unproven supplements and fad diets as somehow safer and more effective than statin therapy: “The widespread advocacy of unproven alternative cholesterol-lowering therapies traces its origins to the passage of the Dietary Supplement Health and Education Act of 1994 (DSHEA). I have fell for the misinformation peddled by the likes of spacedoc,McKendrick and Sinatra and co for years. Therefore, we performed a meta-analysis of relevant observational studies to quantify the magnitude of the association between statin therapy and the risk of dementia. ... 18 November 2019 • 7:00pm. The brain uses cholesterol to manufacture neurotransmitters, the chemicals which enable brain cells to communicate with each other. Now there’s food for thought. ( Please note, he has published and presented literally hundreds of case studies and primary research in the US and internationally.) So the bottom line is that if you are diagnosed with CVD disease and have LDL > 100 mg/dl, statins will lower morbidity and mortality. No more doubts . I responded with “let me see what I can find,” although I was concerned that this reporter was searching for a cardiologist to support attention-grabbing claims of severe side effects of statins rather than seeking a balanced, unbiased perspective from a knowledgeable and experienced cardiologist. The Science, The Media, The Statin-Denialist Cult, and The Nocebo Effect” which concluded that there was no scientific evidence for cognitive side effects of the widely-utilized statin cholesterol lowering drugs. NIH-funded clinical trial will test statins in 20,000 older adults. “Hardening of the arteries”. Nearly 2 decades after the DSHEA was passed, the array of worthless or harmful dietary supplements on the market is staggering, amounting to more than $30 billion in yearly sales. Any chance “lead-in-periods” which exclude those most likely to experience a side effects from the study population might skew the ‘no-side-effect’ conclusions in studies? There is some filtering out of those individuals who can’t tolerate the study medication. on again off again before my triple bypass 13 years ago. However, recently there have been concerns over their side effects. Statins are one of the most commonly prescribed drugs for high cholesterol in the United States.
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